Biography
Dr Andrea Alexandre graduated with honors in medicine and surgery at the prestigious Campus Bio-Medico University of Rome.
During his university years he attended the neurosurgery department of Queen Mary University Hospital in London as a "medical elective student" and later that of Imperial College University - West London Neuroscience Center, also in London, with Prof. F.Afshar.
He continued his studies obtaining his specialization in Radiology (Diagnostic Imaging), always with honors, at the prestigious Catholic University of the Sacred Heart in Rome, with prof. Cesare Colosimo.
During the specialization he attends the Complex Operative Unit of Neuroradiology of Cesena for a period of six months.
He finished his training in Paris, where he completed a fellowship in interventional neuroradiology, at the Neuri center (Brain Vascular Center) in Beaujon and Bicêtre hospitals, for a period of two years, focusing in the minimally invasive treatment of cerebral vascular malformations, with the Prof J.Moret and L.Spelle.
At the same time, he specialized in the minimally invasive treatment of degenerative pathologies of the spine, at the EU.N.I. center (European Neurosurgical Institute) of Treviso
He currently works as a Neuroradiologist in the Complex Operative Unit of Radiology and Neuroradiology of the A.Gemelli University Polyclinic Foundation IRCCS in Rome.
Main research fields of dr. Alexandre are the diagnostic and interventional techniques in cerebro-vascular and spine diseases.
Diagnostic techniques (imaging in neuroradiology) include magnetic resonance imaging, CT, digital subtraction angiography (DSA) and traditional radiology.
Interventional techniques include:
1) minimally invasive treatments for aneurysms, fistulas and cerebral vascular malformations, performed endovascularly;
2) minimally invasive procedures for degenerative pathologies of the spine, such as herniated discs, disc degeneration and spinal canal stenosis, performed percutaneously, without surgical incisions.
Education & Training
2015-today
Neuroradiologist in the Complex Operative Unit of Radiology and Neuroradiology, Fondazione Policlinico Universitario A.Gemelli IRCCS, Roma
2023
Abilitazione Scientifica Nazionale a Professore di II Fascia, Settore concorsuale 06/I1
Diagnostica per Immagini, Radioterapia e Neuroradiologia
2022
Harvard Medical School Postgraduate Medical Education, Foundation of Clinical Research
2021-2022
Master Universitario di II livello: Ricerca Clinica
Università Campus Bio-Medico di Roma
2014-2015
Fellowship Neuri Brain Vascular Center, Paris
2009-2014
Residency in Radiology, Università Cattolica del Sacro Cuore, Roma
2008
Degree in Medicine and Surgery, Università Campus Bio-Medico di Roma
Scientific Activity
- Interv Neuroradiol 2019, Pre-operative direct puncture embolization of head and neck hypervascular tumors using SQUID 12. -
OBJECTIVE: The authors have evaluated their experience in pre-operative direct puncture embolization of hypervascular tumors of the head and neck using SQUID 12, an embolic liquid agent.
METHODS:
Between July 2016 and March 2019, the authors retrospectively reviewed clinical, embolization and surgical data of 11 consecutive patients with 12 hypervascular head and neck tumors who had undergone pre-operative embolization using SQUID 12. Percutaneous embolizations were performed by inserting a 19-22 Gauge needle directly into the tumor under ultrasound, fluoroscopic and/or endoscopic guidance. The hub of the needle was connected to a 15-cm DMSO-compatible extension tube, and the SQUID 12 was injected.
RESULTS:
Total or near-total devascularization was achieved in 11 over 12 cases. Complete en-bloc tumor removal by surgery was achieved in all cases. Only one patient required blood transfusion. No major periprocedural adverse events were recorded.
CONCLUSIONS:
Direct puncture embolization of hypervascular tumors of the head and neck using SQUID 12 seems to be safe and effective. It may offer almost complete devascularization due to homogenous, deep penetration in the tumor, with optimal visibility of the agent throughout the percutaneous procedure. It may reduce intraoperative blood loss and the need for transfusion, thus facilitating complete surgical resection.
- J Neuroradiol 2019, The low-profile Neuroform Atlas stent in the treatment of wide-necked intracranial aneurysms - immediate and midterm results: An Italian multicenter registry. -
BACKGROUND AND PURPOSE: Wide-necked brain aneurysms therapy remains a challenge for neurointerventionalists, mainly for the high recurrence rate. Low-profile stents make feasible the treatment of these aneurysms. In our multicenter series we analyzed clinical and angiographic results of Neuroform Atlas stent-assisted coiling.
MATERIALS AND METHODS:
From January 2016 to March 2017, 113 wide-necked aneurysms were discovered with CTA, MRA and DSA. The Atlas stent-assisted coiling procedures were performed under general anesthesia with sequential or jailing techniques. Six months follow-up DSA was performed to assess the recurrence rate through the modified Raymond-Roy occlusion scale (RROC). Moreover, patients were evaluated clinically to analyse the degree of disability according to the mRS. MRI was performed at 12 months evaluating both the cerebral tissue and the vessels.
RESULTS:
In all the procedures it was feasible to navigate the Neuroform Atlas to the goal vessel and deploy the stent across the aneurysmal neck. Intra-procedural complications account for the 6.2% (7/113). The immediate occlusion rate was RROC 1 in 88%, 2 in 9% and 3 in 3% of cases. The 6 months clinical data showed mRS Score 0-1 in 96.5% of patients; 3 patients died of complications related to SAH. The 12 months follow-up showed RROC of 1 in 82%, 2 in 13% and 3 in 5% of cases. No aneurysm has been retreated.
CONCLUSIONS:
In our multicenter experience the Neuroform Atlas stent assisted-coiling has shown to be a safe and effective technique for the treatment of wide-necked intracranial aneurysms with encouraging clinical and angiographic results.
Awards
- 2019 -
Top Oral Paper Award, World Congress of Interventional Neuroradiology (WFITN 2019, Napoli)
- 2012 -
Didactic Poster, Certificato di Merito. 45^ SIRM Congress, Torino, June 1-5, 2012.
- 2010 -
Didactic Poster, Certificato di Merito. 44^ SIRM Congress, Verona, June 10-15, 2010.